Manganese, monoamine metabolite levels at birth, and child psychomotor development
Identifieur interne : 000280 ( France/Analysis ); précédent : 000279; suivant : 000281Manganese, monoamine metabolite levels at birth, and child psychomotor development
Auteurs : Larissa Takser [France] ; Donna Mergler [Canada] ; Georgette Hellier [France] ; Josiane Sahuquillo [France] ; Guy Huel [France]Source :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Manganèse, Métal lourd, Homme, Enfant.
English descriptors
- KwdEn :
Abstract
Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: attention (partial r = -0.33, P < 0.001), non-verbal memory (partial r = -0.28, P < 0.01 ), and hand skills (partial r = -0.22, P < 0.05), No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000A48
- to stream PascalFrancis, to step Curation: 000275
- to stream PascalFrancis, to step Checkpoint: 000943
- to stream Main, to step Merge: 003329
- to stream Main, to step Curation: 002F24
- to stream Main, to step Exploration: 002F24
- to stream France, to step Extraction: 000280
Links to Exploration step
Pascal:03-0433727Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Manganese, monoamine metabolite levels at birth, and child psychomotor development</title><author><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>CINBIOSE, Université du Québec à Montréal</s1><s2>Montréal, Que.</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0433727</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0433727 INIST</idno><idno type="RBID">Pascal:03-0433727</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A48</idno><idno type="wicri:Area/PascalFrancis/Curation">000275</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000943</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000943</idno><idno type="wicri:doubleKey">0161-813X:2003:Takser L:manganese:monoamine:metabolite</idno><idno type="wicri:Area/Main/Merge">003329</idno><idno type="wicri:Area/Main/Curation">002F24</idno><idno type="wicri:Area/Main/Exploration">002F24</idno><idno type="wicri:Area/France/Extraction">000280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Manganese, monoamine metabolite levels at birth, and child psychomotor development</title><author><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>CINBIOSE, Université du Québec à Montréal</s1><s2>Montréal, Que.</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Dopamine</term><term>Heavy metal</term><term>Human</term><term>Low dose</term><term>Manganese</term><term>Pregnancy</term><term>Progeny</term><term>Psychomotor development</term><term>Serotonin</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Manganèse</term><term>Métal lourd</term><term>Toxicité</term><term>Dose faible</term><term>Gestation</term><term>Descendance</term><term>Homme</term><term>Développement psychomoteur</term><term>Enfant</term><term>Dopamine</term><term>Sérotonine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Manganèse</term><term>Métal lourd</term><term>Homme</term><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: attention (partial r = -0.33, P < 0.001), non-verbal memory (partial r = -0.28, P < 0.01 ), and hand skills (partial r = -0.22, P < 0.05), No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Québec</li><li>Île-de-France</li></region><settlement><li>Montréal</li><li>Villejuif</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name></region><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name></country><country name="Canada"><region name="Québec"><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000280 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000280 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= Pascal:03-0433727
|texte= Manganese, monoamine metabolite levels at birth, and child psychomotor development
}}
| This area was generated with Dilib version V0.6.29. |  |